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AMD CPU Limitations in macOS
Unfortunately many features in macOS are outright unsupported with AMD and many others being partially broken. These include:
Virtual Machines relying on AppleHV
This includes VMWare, Parallels, Docker, Android Studio, etc
VirtualBox is the sole exception as they have their own hypervisor
VMware 10 and Parallels 13.1.0 do support their own hypervisor, however using such outdated VM software poses a large security threat
Adobe Support
Most of Adobe's suite relies on Intel's Memfast instruction set, resulting in crashes with AMD CPUs
You can disable functionality like RAW support to avoid the crashing: Adobe Fixes(opens new window)
32-Bit support
For those still relying on 32-Bit software in Mojave and below, note that the Vanilla patches do not support 32-bit instructions
A work-around is to install a custom kernel (opens new window), however you lose iMessage support and no support is provided for these kernels
Stability issues on many apps
Audio-based apps are the most prone to issues, ie. Logic Pro
DaVinci Resolve has been known to have sporadic issues as well
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